Tropinone reductase I
| tropine dehydrogenase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 1.1.1.206 | ||||||
| CAS number | 118390-87-7 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a tropinone reductase I (EC 1.1.1.206) is an enzyme that catalyzes the chemical reaction
- tropine + NADP+
tropinone + NADPH + H+
Thus, the two substrates of this enzyme are tropine and NADP+, whereas its 3 products are tropinone, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is tropine:NADP+ 3alpha-oxidoreductase. Other names in common use include tropine dehydrogenase, tropinone reductase (ambiguous), and TR-I. This enzyme participates in alkaloid biosynthesis ii.
References
- Koelen KJ and Gross, GG (1982). "Partial purification and properties of tropine dehydrogenase from root cultures of Datura stramonium". Planta Med. 44 (4): 227–230. doi:10.1055/s-2007-971454. PMID 17402126.
- Couladis MM, Friesen JB, Landgrebe ME and Leete E (1991). "Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia". Pytochemistry 30 (3): 801–805. doi:10.1016/0031-9422(91)85255-X.
- Nakajima K, Hashimoto T, Yamada Y (1993). "Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor". Proc. Natl. Acad. Sci. U. S. A. 90 (20): 9591–5. doi:10.1073/pnas.90.20.9591. PMC 47615. PMID 8415746. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47615.
- Drager B (2006). "Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism". Phytochemistry. 67 (4): 327–37. doi:10.1016/j.phytochem.2005.12.001. PMID 16426652.